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Anemia:
Decrease in the oxygen-carrying capacity of the blood; indicated by a low hematocrit (Hct) and hemoglobin (Hb) concentration.
Anomaly:
Deviation from what is regarded as normal; congenital malformation; birth defect.
B Cells:
Type of lymphocyte especially involved in the production of antibodies.
Basophil:
Type of white blood cell; a type of granulocyte involved in allergic reactions; normal value: 0.5-2% or 25-100 per microliter.
Bone Marrow:
Soft tissue within the bones where blood cells are manufactured.
Bone Marrow Aspiration:
Test in which a sample of bone marrow cells is removed from the bone marrow with a needle and examined under a microscope.
Bone Marrow Transplant (BMT):
Procedure in which bone marrow of the patient is destroyed by chemotherapy and/or radiation and then replaced with healthy cells from a compatible donor; also known as Stem Cell Transplant.
Chelation:
A system to remove excess iron from the blood and tissues.
Chronic:
Of long duration; designates a condition or disease showing little change or of slow progression.
Complete Blood Count (CBC):
Amount or level of blood cells: white cells, red cells, and platelets in the peripheral blood.
Congenital:
Present at birth.
Cross Match:
Type and cross; test in which the blood cells of a donor and a recipient are determined to be compatible or not compatible for a transfusion.
Cytokines:
Growth factors which promote the proliferation and maturation of blood cells; chemicals which are produced naturally by the body and which help to regulate cell growth.
Diamond Blackfan Anemia (DBA):
A rare pure red blood cell anemia beginning in infancy and childhood and resulting from the failure of the bone marrow to produce red blood cells.
Differential:
Percent of different types of white blood cells in the blood.
Dominant: In genetics, a trait or characteristic that may be expressed in the offspring even though it is carried on only one of the homologous (parental) chromosomes.
Endocrine: System to secrete; the network of ductless glands and other structures that elaborate and secrete hormones directly into the blood stream, affecting the function of specific target organs.
Eosinophil: Type of white blood cell, i.e., neutrophil; involved in allergic reaction; normal value 2-3%.
Erythrocyte: A red blood cell. Etiology: The cause of a disease. Fetal
Hemoglobin: Type of oxygen carrying molecule present in the fetus and infant. Forms more than half of the hemoglobin of the fetus and present in minimal amounts in children and adults. Abnormally elevated in certain blood disorders.
Granulocyte: Type of white blood cell; one example is a neutrophil.
Hematology: Study of the blood.
Hematocrit (Hct): Portion of the blood's total volume that is made up of red blood cells. Normal values vary: men 45% to 57%; women 37% to 47%; children (depending on age) 36% to 46%.
Hemoglobin (Hgb or Hb): iron-containing molecules in the blood that imparts the color to blood; combines with oxygen from the lungs and carries it to the body's cells. Normal values for men: 14 to 16 g/dl; women: 12 to 14 g/dl; children: 12 to 14 g/dl.
Hypoplastic: Incomplete or underdevelopment of an organ or tissue.
Hypertension: A common, often asymptomatic disorder characterized by elevated blood pressure persistently exceeding 140/90 mm Hg in adults; and for children, exceeding what is normal for the child's age.
Leukocyte: White blood cell; includes granulocytes, lymphocytes, basophils, and eosinophils.
Liver Biopsy: A needle is inserted into the liver and a sample taken to determine iron liver stores.
Lymphocyte: A white blood cell formed in lymphoid tissue throughout the body, e.g., lymph nodes, spleen, thymus, tonsils, and sometimes in bone marrow.
Macrocytes: Abnormally large erythrocytes.
Megakaryocytes: Large cells in the bone marrow from which pieces break off to form platelets.
Neutropenia: Low neutrophil (poly) count.
Neutrophil: Type of white blood cell that fights infection; also called polymorphonuclear leukocyte (poly). Normal values depend on age but are generally 50-60 percent of 4,000 to 10,000 in number. For those under age 5, normal values are less than 50%.
Normocellular: Having a normal number of cellular elements in general; not devoid of cells.
Normochromic: Normal color of erythrocytes; normal amount of hemoglobin in each red cell.
Osteoporosis: Loss of bone calcareous matter and increased bone porosity.
Pancytopenia: Low number of all blood cells. Parvovirus B-19: The cause of a usually benign disease known as Fifth disease; in immunocompromised patients, may cause aplastic anemia.
Platelets: Blood cells which form clots thereby preventing bleeding and bruising. Normal values range from 150,000 to 400,000 per microliter of blood. A count below 50,000 can result in spontaneous bleeding; a count below 5,000 can put the patient at risk of severe life-threatening bleeds.
Precursors: A substance that precedes another substance.
Progenitor: Those young cells that should normally mature into red cells; anything that originates or precedes.
Red Blood Cell (RBC): Oxygen-carrying cell in the blood that contains the pigment hemoglobin, produced in the bone marrow; erythrocyte. Counts refer to the number of cells in a microliter of blood. Normal ranges vary according to sex and age.
Reticulocyte (Retic) Count: Number of young red blood cells. Immature RBCs/Total RBCs x 100% = retic count.
Reticulocytopenia: Deficiency of reticulocytes in the blood.
SQUID: A non-invasive machine that uses magnetic principles to determine liver iron stores.
Stem Cell: Cell from which platelets, red blood cells, and/or white cells grow in the bone marrow.
Thrombocyte: Platelet, clotting factor in the blood.
Thrombocytopenia: Low platelet count. Thymocytes: T cells; lymphocytes arising in the thymus.
White Blood Cells(WBC): Blood cells that fight infection. Normal values range from 4,000 to 10,000 cells per microliter of blood but can be greatly altered by factors such as stress, exercise and disease.
 
 
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